Vivere Longevity — Women’s Precision Protocol

Post-Menopausal &
Cardiometabolic Health

Protecting your heart, bones, and muscle mass in the decades that define your healthspan — with evidence that goes far beyond a standard health screen.

The Post-Menopausal Inflection Point

When oestrogen withdraws, biology accelerates — across multiple simultaneous pathways.

Menopause is not simply the end of reproductive cycles. It is the simultaneous withdrawal of a hormone that has been protecting your cardiovascular, skeletal, and metabolic systems at once. The result is not gradual aging — it is an active acceleration. Standard health screens are not designed to detect this transition while there is still time to act on it.

The Vivere Post-Menopausal Protocol targets the hallmarks of aging most accelerated by oestrogen withdrawal — with investigations selected for clinical actionability and interventions ranked by evidence strength and impact. This is not a screening exercise. It is a biological age reversal programme.

Cardiovascular Longevity Bone Density Sarcopenia Prevention Metabolic Resilience Biological Age Reversal MHT Eligibility
Molecular Basis

Six Hallmarks of Aging Critically Accelerated Post-Menopause

Each investigation in our panel maps to a specific molecular pathway — from epigenetic drift to mitochondrial decline, cellular senescence, and the loss of bone and muscle stem cell populations.

H1
Genomic Instability
H2
Telomere Attrition
H3
Epigenetic Alterations
H4
Loss of Proteostasis
H5
Disabled Macroautophagy
H6
Mitochondrial Dysfunction
H7
Cellular Senescence
H8
Stem Cell Exhaustion
H9
Altered Intercellular Communication
H10
Chronic Inflammation
H11
Dysbiosis
H12
Deregulated Nutrient Sensing

López-Otín et al., Cell 2023. Highlighted hallmarks reflect primary mechanistic targets of this protocol.

Precision Investigations

Your Post-Menopausal Biomarker Panel

Seven investigation sets, each selected because it unlocks a high-impact, modifiable intervention — not because it generates data.

The MHT Eligibility Gate: Coronary Artery Calcium Score (CAC)

A single low-radiation CT scan that maps calcium deposits in your coronary arteries. The result directly gates your MHT eligibility and determines your precise 10-year cardiac risk programme.

CAC = 0
10-yr MACE risk ~1–2%. MHT is safe to initiate. Statin deferral is safe.
CAC 1–99
Moderate risk. MHT benefit-risk discussion. Statin consideration.
CAC 100–399
High risk. MHT not recommended for CV benefit. High-intensity statin.
CAC ≥400
Very high risk. MHT contraindicated for cardiovascular purposes.
Your Vivere Journey

From First Assessment to Biological Age Reversal

A structured six-step programme that maps your cardiometabolic risk trajectory, determines your MHT eligibility, and delivers an evidence-ranked intervention plan.

The Biological Age Reversal Triad

Three lifestyle interventions with converging evidence for epigenetic age reversal — your programme is built around these as its non-negotiable foundation.

☀️
Morning Light
Natural light exposure shortly after waking anchors your daily biological rhythm.
🚶‍♀️
Light Physical Activity
A morning walk, ideally combined with your light exposure window.
⏱️
Fasting Window
Time-restricted eating aligned to support metabolic and cellular repair.
1

Longevity Consultation

Physician-led review of your menopause history, cardiovascular risk, and current symptoms.

2

Cardiovascular & Hormonal Bloods

Fasting blood panel covering cardiovascular risk, hormonal status, and bone health.

3

Coronary Artery Calcium Score

A 10-minute CT scan that determines MHT safety and your 10-year cardiac risk.

4

DEXA Body Composition

Bone density, muscle mass, and body fat in one 20-minute scan with sarcopenia screening.

5

Epigenetic Age Clock

DNA methylation test measuring biological age and pace of aging.

6

Protocol Review & Programme

Your physician presents a precision plan for hormone therapy, training, and nutrition based on your results.

Every result is reviewed in a physician-led consultation. Your protocol is built on your data, not a template.

Book a Consultation

Begin Your Post-Menopausal
Longevity Assessment

Vivere Longevity · 290 Orchard Road, #17-11 Paragon Medical, Singapore · By appointment

Book a Consultation